反应详情

Hydrolyze 4-[1-(2-methyl-thiazol-4-ylmethyl)-1H-benzoimidazol-2-yl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester (0.59 g, 1.38 mmol) by refluxing with hydriodic acid (57%, 3.04 mmol) in methanol (10 mL) for 10 hours. Concentrate to remove the methanol, add ether (70 mL) and allow the resultant slurry to stand for 1 hour. Decant the supernatant and dry the solid residue in vacuo at 60° C. to provide 0.78 g of 2-[1,4]diazepan-1-yl-1-(2-methyl-thiazol-4-ylmethyl)-1H-benzoimidazole dihydroiodide.

1. concentrationConcentrate
2. customto remove the methanol
3. additionadd ether (70 mL)
4. customDecant the supernatant and
5. customdry the solid residue in vacuo at 60° C.