HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen iodide → 1-cyclopropylmethyl-2-[1,4]diazepan-1-yl-1H-benzoimidazole dihydroiodide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen iodide | HCID 24841 | — |
| Reactant | 4-(1-cyclopropylmethyl-1H-benzoimidazol-2-yl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester | HCID 70147613 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-cyclopropylmethyl-2-[1,4]diazepan-1-yl-1H-benzoimidazole dihydroiodide | HCID 18464665 | — |
Reaction Steps
Hydrolyze 4-(1-cyclopropylmethyl-1H-benzoimidazol-2-yl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester (0.70 g, 1.81 mmol) by refluxing an ethanol (10 mL) solution of the compound with hydroiodic acid (57%, 5 mL) for 1 hour as described in Example 111 to provide 1-cyclopropylmethyl-2-[1,4]diazepan-1-yl-1H-benzoimidazole dihydroiodide (0.85 g)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06423704B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-5c6765b33d6f4c38a8c95749c95c422a |
| Source note | uspto-grants-2002_07 |