反应详情

Hydrolyze 4-(1-cyclopropylmethyl-1H-benzoimidazol-2-yl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester (0.70 g, 1.81 mmol) by refluxing an ethanol (10 mL) solution of the compound with hydroiodic acid (57%, 5 mL) for 1 hour as described in Example 111 to provide 1-cyclopropylmethyl-2-[1,4]diazepan-1-yl-1H-benzoimidazole dihydroiodide (0.85 g)