反应详情

Stir a mixture of 2-methoxy-5-(2-methoxy-ethoxy)-benzoic acid methyl ester (0.87 g, 3.6 mmol), methanol (20 mL) and 1N NaOH solution (20 mL) for two hours at room temperature. Acidify the reaction with 1N HCl and extract with dichloromethane. Dry (MgSO4) the organic phase, filter and concentrate the filtrate in vacuo. Vacuum dry the residue at room temperature over 48 hours to afford 0.82 g of 2-methoxy-5-(2-methoxy-ethoxy)-benzoic acid as an oil, Rf=0.84 (silica gel, dichloromethane:methanol:acetic acid, 85:10:5).

1. extractionextract with dichloromethane
2. dry with materialDry (MgSO4) the organic phase
3. filtrationfilter
4. concentrationconcentrate the filtrate in vacuo
5. customVacuum dry the residue at room temperature over 48 hours