5-Methyl-2-hexanone → 3-Chloro-5-methylhexan-2-one

HRID 2230765Notes

Reaction equation

[CH3:1][CH:2]([CH3:8])[CH2:3][CH2:4][C:5](=[O:7])[CH3:6].S(Cl)([Cl:12])(=O)=O>>[Cl:12][CH:4]([CH2:3][CH:2]([CH3:8])[CH3:1])[C:5](=[O:7])[CH3:6]

Participants

Reactant 2

HCID 80345-Methyl-2-hexanone

HCID 24648Sulfuryl chloride

Product 1

HCID 109756493-Chloro-5-methylhexan-2-one

Procedure

The process for preparing the α-hydroxyketones of the invention starts from inexpensive 5-methyl-2-hexanone which is reacted with sulfuryl chloride in a first step to give 3-chloro-5-methyl-2-hexanone with high selectivity, as set forth below:

Sources & evidence

ORD record: ord-18e7459935b44be4b481181c3297ab5c
Source dataset: uspto-grants-2002_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06426108B1

Reaction notes

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