反应详情

温度

50 °C

4N Aqueous solution of sodium hydroxide (2 ml) was added to a solution of ethyl 3-(benzoylamino)benzoate (695 mg) in ethanol (5 ml) and 1,4-dioxane (5 ml). After stirred at 50° C. for 1 hour, the mixture was acidified with dilute hydrochloric acid and extracted with ethyl acetate. The organic phase was washed with dilute hydrochloric acid and brine, dried over magnesium sulfate and concentrated to give 3-(benzoylamino)benzoic acid (595 mg) as solid.

1. extractionextracted with ethyl acetate
2. washThe organic phase was washed with dilute hydrochloric acid and brine
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated