反应详情

A mixture of 2-[3-(2-naphthyl)phenylamino]-3-nitropyridine (3.0 g), iron (2.46 g) and acetic acid (5.28 g) in ethanol (14 ml) was stirred under reflux for 6 hours. The reaction mixture was diluted with chloroform, filtered and treated with saturated sodium bicarbonate solution. The chloroform layer was separated, dried, evaporated and chromatographed on silica gel to give 2-[3-(2-naphthyl)phenylamino]-3-aminopyridine (1.2 g, 43.9%).

1. temperatureunder reflux for 6 hours
2. filtrationfiltered
3. additiontreated with saturated sodium bicarbonate solution
4. customThe chloroform layer was separated
5. customdried
6. customevaporated
7. customchromatographed on silica gel