Hydrochloric Acid → 4-(3-Amino-5-methoxycarbonylphenyl)-2-(3-pyridylmethyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine.dihydrochloride

HRID 2231045Notes

Reaction equation

HRID 2231045 reaction equation
C([NH:4][C:5]1[CH:6]=[C:7]([N:15]2[C:20](=[O:21])[C:19]([CH2:22][C:23]3[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=3)=[N:18][C:17]3[CH:29]=[CH:30][CH:31]=[N:32][C:16]2=3)[CH:8]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:10]=1)(=O)C.[ClH:33]>CO>[ClH:33].[ClH:33].[NH2:4][C:5]1[CH:6]=[C:7]([N:15]2[C:20](=[O:21])[C:19]([CH2:22][C:23]3[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=3)=[N:18][C:17]3[CH:29]=[CH:30][CH:31]=[N:32][C:16]2=3)[CH:8]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22724524HCID 22724524, compound

Product 1

HCID 227243024-(3-Amino-5-methoxycarbonylphenyl)-2-(3-pyridylmethyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine.dihydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 4-(3-acetylamino-5-methoxycarbonylphenyl)-2-(3-pyridylmethyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine (847 mg) and hydrochloric acid (35%, 1 ml) in methanol (10 ml) was stirred under reflux for 2 hours. After cooling, the resultant precipitate was collected and washed with methanol to give 4-(3-amino-5-methoxycarbonylphenyl)-2-(3-pyridylmethyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazinedihydrochloride (612 mg).

Workup

  1. temperatureunder reflux for 2 hours
  2. temperatureAfter cooling
  3. customthe resultant precipitate was collected
  4. washwashed with methanol

Sources & evidence

ORD record
ord-6ac0a77273334568b408c314c3f8a7d9
Source dataset
uspto-grants-2002_07
Patent number
US06426345B1

Reaction notes

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