Acetonitrile → Debrisoquine

HRID 2231166Notes

Reaction equation

HRID 2231166 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][NH:2]1.N[N:12]=[CH:13]S(O)(=O)=O.C(#[N:20])C>>[CH:7]1[CH:8]=[CH:9][C:10]2[CH2:1][N:2]([C:13]([NH2:12])=[NH:20])[CH2:3][CH2:4][C:5]=2[CH:6]=1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 70461,2,3,4-TetrahydroisoquinolineHCID 3013981Aminoiminomethane-sulphonic acid

Product 1

HCID 2966Debrisoquine

Procedure

Tetrahydroisoquinoline (0.013 m) is treated with aminoiminomethanesulfonic acid (0.01 m) at ambient temperature. After completion of the reaction, it is diluted with acetonitrile, cooled and the solid product is collected by filtration.

Workup

  1. customAfter completion of the reaction, it
  2. temperaturecooled
  3. filtrationthe solid product is collected by filtration

Sources & evidence

ORD record
ord-b58048d523de4aaeb385546b3715860b
Source dataset
uspto-grants-1988_11
Patent number
US04781866

Reaction notes

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