Hydrochloric Acid → HCID 67863671, compound

HRID 2231192Notes

Reaction equation

HRID 2231192 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:17]2[C:22](=[O:23])[NH:21][C:20](=[O:24])[CH:19]=[N:18]2)[CH:5]=[C:6]([Cl:16])[C:7]=1[S:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=1.[Sn](Cl)Cl.Cl>C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([N:17]2[C:22](=[O:23])[NH:21][C:20](=[O:24])[CH2:19][NH:18]2)[CH:5]=[C:6]([Cl:16])[C:7]=1[S:8][C:9]1[CH:10]=[CH:11][C:12]([CH3:15])=[CH:13][CH:14]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 24479Stannous ChlorideHCID 86741257HCID 86741257, compound

Product 1

HCID 67863671HCID 67863671, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

20 g of 2-[3,5-dichloro-4-(4-methylthiophenoxy)phenyl]-1,2,4-triazine-3,5-(2H,4H)-dione were dissolved in 200 ml of hot glacial acetic acid. 25 g of tin(II) chloride.2H2O, followed by 100 ml of concentrated hydrochloric acid, were added, and then the mixture was heated to reflux for four hours. After the mixture had been cooled, the product was filtered off with suction, washed to neutrality with water, and recrystallized from 2-methoxyethanol, melting point 239° C.

Workup

  1. additionwere added
  2. temperaturethe mixture was heated
  3. temperatureto reflux for four hours
  4. temperatureAfter the mixture had been cooled
  5. filtrationthe product was filtered off with suction
  6. washwashed
  7. customrecrystallized from 2-methoxyethanol, melting point 239° C.

Sources & evidence

ORD record
ord-48dc702489d842e5b317707bab558999
Source dataset
uspto-grants-1988_11
Patent number
US04782056

Reaction notes

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