反应详情

To a mixture of 2-amino-3-hydroxypyridine (7.64 g) and Adogen 464 (Trademark: prepared by Aldrich Chemical Co.) (0.42 g) in 40% aqueous sodium hydroxide (35 ml) and methylene chloride (35 ml) was added 2-methoxybenzyl chloride (10.87 g) at ambient temperature. After being stirred for 22 hours, the organic layer was separated and the aqueous layer was extracted with methylene chloride. The combined extracts were washed with saturated sodium chloride aqueous solution, dried over magnesium sulfate, and evaporated in vacuo. The crystalline residue was recrystallized from ethyl acetate to give 2-amino-3-(2-methoxybenzyloxy)pyridine (6.09 g).

1. customthe organic layer was separated
2. extractionthe aqueous layer was extracted with methylene chloride
3. washThe combined extracts were washed with saturated sodium chloride aqueous solution
4. dry with materialdried over magnesium sulfate
5. customevaporated in vacuo
6. customThe crystalline residue was recrystallized from ethyl acetate