Methyl iodide → HCID 21286356, compound

HRID 2231198Notes

Reaction equation

HRID 2231198 reaction equation
[CH3:1][I:2].[CH3:3][N:4]([CH2:6][C:7]1[N:11]2[CH:12]=[CH:13][CH:14]=[C:15]([O:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH3:25])[C:10]2=[N:9][C:8]=1[CH3:26])[CH3:5]>CC(C)=O.C(Cl)(Cl)Cl>[I-:2].[CH3:25][O:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[CH2:17][O:16][C:15]1[C:10]2[N:11]([C:7]([CH2:6][N+:4]([CH3:1])([CH3:3])[CH3:5])=[C:8]([CH3:26])[N:9]=2)[CH:12]=[CH:13][CH:14]=1

Participants

5

Reactant 2

HCID 6328Methyl iodideHCID 21286361HCID 21286361, compound

Product 1

HCID 21286356HCID 21286356, compoundYield 102.1%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 6212ChloroformSolvent

Procedure

Methyl iodide (1.08 g) was added dropwise to a solution of 3-dimethylaminomethyl-8-(2-methoxybenzyloxy)2-methylimidazo[1,2-a]pyridine (3.42 g) in acetone (34 ml) and chloroform (10 ml) at room temperature and the mixture was stirred for 24 hours. The resulting precipitate was collected by filtration, washed with acetone, and dried in a desiccator to give 8-(2-methoxybenzyloxy)-2-methyl-3-trimethylammoniomethylimidazo[1,2-a]pyridine iodide (3.63 g).

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with acetone
  3. customdried in a desiccator

Sources & evidence

ORD record
ord-985a1e89a6ee4d6eaf0135a20119598f
Source dataset
uspto-grants-1988_11
Patent number
US04782055

Reaction notes

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