反应详情

The aminonitrile (1.108 mol) is added over a ten minute period to a stirred solution of 2,3-pyridinedicarboxylic anhydride (1.0 mol) containing acetic acid (2.0 mol) in toluene, while maintaining the temperature of the reaction mixture below 25° C. Upon completion of the aminonitrile addition the reaction mixture is stirred for one and one-half hrs and then weighed and analyzed by high performance liquid chromatography for the desired 2-carbamoyl nicotinic acid.

1. temperaturewhile maintaining the temperature of the reaction mixture below 25° C