HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 2-[(1-Cyano-1,2-dimethylpropyl)aminocarbonyl]nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Furo[3,4-b]pyridine-5,7-dione | HCID 69688 | — |
| Reactant | 2-Carbamoylpyridine-3-carboxylic acid | HCID 258810 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-[(1-Cyano-1,2-dimethylpropyl)aminocarbonyl]nicotinic acid | HCID 13563610 | — |
Reaction Steps
The aminonitrile (1.108 mol) is added over a ten minute period to a stirred solution of 2,3-pyridinedicarboxylic anhydride (1.0 mol) containing acetic acid (2.0 mol) in toluene, while maintaining the temperature of the reaction mixture below 25° C. Upon completion of the aminonitrile addition the reaction mixture is stirred for one and one-half hrs and then weighed and analyzed by high performance liquid chromatography for the desired 2-carbamoyl nicotinic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04782157 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-9aee0ee399a14317a1eadad5ebbdcc36 |
| Source note | uspto-grants-1988_11 |