Methanol → HCID 86742519, compound

HRID 2231397Notes

Reaction equation

HRID 2231397 reaction equation
C(OC=CC[S:8]C)(=O)C.CO.[C]=O.[C:14]([O:17][CH:18]([CH2:23][CH2:24][S:25][CH3:26])[C:19]([O:21][CH3:22])=O)(=[O:16])[CH3:15]>O1CCCC1.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.C1(C)C=CC=CC=1>[C:14]([O:17][CH:18]([CH2:23][CH2:24][S:25][CH3:26])[C:19]([O:21][CH3:22])=[S:8])(=[O:16])[CH3:15]

Participants

8

Reactant 4

HCID 887MethanolHCID 544393541-Acetoxy-3-methylthiopropeneHCID 86132149HCID 86132149, compoundHCID 178418416HCID 178418416, compound

Product 1

HCID 86742519HCID 86742519, compoundYield 16.8%

Reagents, catalysts & solvents 3

HCID 178418476HCID 178418476, compoundCatalystHCID 1140TolueneSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
100 °C

Procedure

0.5 mmoles 1-acetoxy-3-methylthiopropene, (Z: E ratio 43:5.7), and 10 mmoles methanol were charged into a 71 cc stainless steel bomb equipped with a glass liner and a Teflon coated.stir bar. Ten mole percent, based on 1-acetoxy-3-methylthiopropene, of a catalyst comprising bis(triphenylphosphine)dichloropalladium, (φ3P)2PdCl2, was added. Toluene was included as an internal standard. Five milliliters of tetrahydrofuran as a solvent were also included in the reaction system. The reaction mixture was charged under argon. The bomb was sealed and carbon monoxide at a pressure of 1000 psi (at room temperature) was charged to the bomb, and the bomb was heated to 100° C. and allowed to react for 44 hours with stirring. At the termination of the reaction, the reaction products were analyzed by gas chromatography and it was found that 2-acetoxy-4-(methylthio)butanoic acid, methyl ester was produced in a yield of 28.6 percent, and that 2-acetoxy-4-(methylthio)thiobutanoic acid, methyl ester was produced in a yield of 16.8 percent, based on the 1-acetoxy-3-methylth.1opropene reactant charged. Note that each of the products is hydrolyzable to methionine hydroxy analog.

Workup

  1. customequipped with a glass liner and a Teflon coated.stir bar
  2. additionwas added
  3. additionThe reaction mixture was charged under argon
  4. customThe bomb was sealed
  5. customto react for 44 hours
  6. customAt the termination of the reaction
  7. customwas produced in a yield of 28.6 percent

Sources & evidence

ORD record
ord-906c313b99bd4745ac50a9b2895a239a
Source dataset
uspto-grants-1988_11
Patent number
US04782173

Reaction notes

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