HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2231450Generated: November 2, 2026
Potassium Carbonate → Ethyl 4-(4-acetyl-3-hydroxy-2-propylphenoxy)butanoate
https://huagongshe.com/reaction/2231450
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 4-bromobutyrate | HCID 76300 | — |
| Reactant | 2',4'-Dihydroxy-3'-propylacetophenone | HCID 2775198 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 4-(4-acetyl-3-hydroxy-2-propylphenoxy)butanoate | HCID 14330004 | 32.1% |
Reaction Steps
A mixture of 15.0 g of 1-(2,4-dihydroxy-3-propylphenyl)ethanone, 15.0 g of ethyl 4-bromobutyrate, 16.0 g of anhydrous potassium carbonate in 200 ml of anhydrous dimethylformamide was stirred and heated at 75° C. for 24 hours. The solvent was removed in vacuo and the residue was purified by high pressure liquid chromatography using 2.5% ethyl acetate-toluene to yield 7.62 g of 4-(4-acetyl-3-hydroxy-2-propylphenoxy)butanoic acid ethyl ester as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04782176 |
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| Source dataset | uspto-grants-1988_11 |
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| ORD ID | ord-cc9b4cb8c2404ecc9e36e19af14f8b97 |
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| Source note | uspto-grants-1988_11 |
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