HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dibromopropane → 6-[4-Acetyl-3-(3-bromopropoxy)-2-propylphenoxy]hexanoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dibromopropane | HCID 8001 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 6-(4-acetyl-3-hydroxy-2-propylphenoxy)hexanoate | HCID 14330007 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 6-[4-Acetyl-3-(3-bromopropoxy)-2-propylphenoxy]hexanoic acid methyl ester | HCID 14330008 | 98% |
Reaction Steps
A mixture of 6.0 g of 6-(4-acetyl-3-hydroxy-2-propylphenoxy)hexanoic acid methyl ester, 19 ml of 1,3-dibromopropane and 2.0 g of anhydrous potassium carbonate in 175 ml of anhydrous acetone was stirred at reflux for 52 hours. The reaction mixture was concentrated in vacuo to give 8.1 g (98% yield) of 6-[4-acetyl-3-(3-bromopropoxy)-2-propylphenoxy]hexanoic acid methyl ester as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04782176 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-81e2ceca30f942979c9c2fe9bc15a9fc |
| Source note | uspto-grants-1988_11 |