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HRID2231460

反应详情

EQUATION

反应方程式

HRID 2231460 的结构方程式

REACTANTS

反应物

3
结构：BrCCCBr
HCID8001

1,3-Dibromopropane

C3H6Br2

结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：CCCc1c(OCCCCCC(=O)OC)ccc(C(C)=O)c1O
HCID14330007

Methyl 6-(4-acetyl-3-hydroxy-2-propylphenoxy)hexanoate

C18H26O5

PRODUCTS

生成物

1
结构：CCCc1c(OCCCCCC(=O)OC)ccc(C(C)=O)c1OCCCBr
HCID14330008

未命名化合物

收率 98%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

A mixture of 6.0 g of 6-(4-acetyl-3-hydroxy-2-propylphenoxy)hexanoic acid methyl ester, 19 ml of 1,3-dibromopropane and 2.0 g of anhydrous potassium carbonate in 175 ml of anhydrous acetone was stirred at reflux for 52 hours. The reaction mixture was concentrated in vacuo to give 8.1 g (98% yield) of 6-[4-acetyl-3-(3-bromopropoxy)-2-propylphenoxy]hexanoic acid methyl ester as an oil.

WORKUP

后处理

  1. temperatureat reflux for 52 hours
  2. concentrationThe reaction mixture was concentrated in vacuo