Hydrogen Bromide → 113884-76-7

HRID 2231507Notes

Reaction equation

HRID 2231507 reaction equation
Cl.C[O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[O:14]C)[CH:10]=[N:9][CH:8]=[CH:7]2.[BrH:16]>>[BrH:16].[OH:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[OH:14])[CH:10]=[N:9][CH:8]=[CH:7]2

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 2128686463768-19-4

Product 1

HCID 135736659113884-76-7Yield 97.6%

Procedure

63.4 g (0.28 mol) of 6,7-dimethoxyisoquinoline hydrochloride was dissolved in 630 ml of 47% hydrobromic acid, and the mixture was refluxed for 24 hours under stirring in nitrogen atmosphere. The reaction mixture was allowed to stand still under cooling with ice. The crystals formed were collected by filtration and washed with cold water and acetone. They were dried in air overnight and then dried at a temperature of from 90° to 95° C. for 6 hours to obtain 66.4 g (yield: 97.6%) of the above identified compound.

Workup

  1. temperaturethe mixture was refluxed for 24 hours
  2. temperatureunder cooling with ice
  3. customThe crystals formed
  4. filtrationwere collected by filtration
  5. washwashed with cold water and acetone
  6. customThey were dried in air overnight
  7. customdried at a temperature of from 90° to 95° C. for 6 hours
  8. customto obtain 66.4 g (yield: 97.6%) of the

Sources & evidence

ORD record
ord-b1790ec008744d5cac8ad4aa2ffd039b
Source dataset
uspto-grants-1988_11
Patent number
US04782155

Reaction notes

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