Hydrochloric Acid → HCID 178502843, compound

HRID 2231599Notes

Reaction equation

HRID 2231599 reaction equation
[OH:1][C:2]1[S:3][CH:4]=[C:5](/[C:7](=[N:12]/[O:13][CH3:14])/[C:8]([O:10]C)=[O:9])[N:6]=1.[OH-].[K+].Cl>C(O)C>[OH:1][C:2]1[S:3][CH:4]=[C:5](/[C:7](=[N:12]/[O:13][CH3:14])/[C:8]([OH:10])=[O:9])[N:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 178502845HCID 178502845, compound

Product 1

HCID 178502843HCID 178502843, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 3 ml of ethanol is dissolved 1.0 g of methyl 2-(2-hydroxy-4-thiazolyl)-(Z)-2-methoxyiminoacetate, and under ice-cooling 5 ml of an aqueous solution of potassium hydroxide (1.3 g) is added dropwise. The mixture is allowed to stand for 4 hours, adjusted to pH 2-3 with 1N hydrochloric acid, and extracted three times with n-butanol. The extracts are combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The procedure gives a light-brown powder of 2-(2-hydroxy-4-thiazolyl)-(Z)-2-methoxyiminoacetic acid, m.p. 143°-144° C. (decomp.).

Workup

  1. additionis added dropwise
  2. extractionextracted three times with n-butanol
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-16025610915a420e82450fe8086e2de1
Source dataset
uspto-grants-1988_11
Patent number
US04782147

Reaction notes

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