HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl methyl ether → 6-(1-methylethoxy)-7-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl methyl ether | HCID 15413 | — |
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 7-[3-(methanesulfonyloxy)propoxy]-6-(1-methylethoxy)-2H-1-benzopyran-2-one | HCID 19927700 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-(1-methylethoxy)-7-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one | HCID 19927722 | 69% |
Reaction Steps
Method B (24 h at 60° C.); starting materials: 7-[3-(methanesulfonyloxy)propoxy]-6-(1-methylethoxy)-2H-1-benzopyran-2-one (example 73) and 4-phenylpiperidine; yield 69%; fusion point 86°-87° C. (from TBME). Fumarate: method E; yield 90%; fusion point 164°-167° C. (from ethanol and acetone).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-839f4529654e48c7bbcee0290e2694f8 |
| Source note | uspto-grants-1995_06 |