Water → HCID 14324491, compound

HRID 2231621Notes

Reaction equation

HRID 2231621 reaction equation
[C:1]([CH2:7][C:8]([O:10]CC)=O)(=O)[C:2]([CH3:5])([CH3:4])[CH3:3].O.[NH2:14][NH2:15].O>C(O)C>[C:2]([CH:1]1[CH2:7][C:8](=[O:10])[NH:15][NH:14]1)([CH3:5])([CH3:4])[CH3:3]

Participants

5

Reactant 3

HCID 962Water2×HCID 24654Hydrazine hydrate (1:1)HCID 86950Ethyl pivaloylacetate

Product 1

HCID 14324491HCID 14324491, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.0 kg of ethyl pivaloylacetate was dissolved in 2.5 liters of ethanol and 320 g of hydrazine hydrate was added dropwise thereto while cooling with water. After the addition, the whole was reacted for one night at room temperature and then 5.0 liters of water was added thereto and the system stirred. The crystals precipitated out were filtered out under reduced pressure, washed fully with water, then with a small amount of methanol and then dried with air. Yield: 812 g, 98.5%.

Workup

  1. additionAfter the addition
  2. customthe whole was reacted for one night at room temperature
  3. customThe crystals precipitated out
  4. filtrationwere filtered out under reduced pressure
  5. washwashed fully with water
  6. dry with materialwith a small amount of methanol and then dried with air

Sources & evidence

ORD record
ord-71de9736dadd4956bca13652951eaec5
Source dataset
uspto-grants-1988_11
Patent number
US04783396

Reaction notes

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