反应详情

A solution of one g of 7-β-D-arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine, 4.3 ml of glacial acetic acid, 50 ml water, and 2.67 g of sodium nitrite is heated at 75° C. for one hour, cooled, and treated with 2.1 g of urea. The solution is evaporated in vacuo and the resulting residue is dissolved in water and treated with 15 ml of wet Dowex 50×8 (in hydrogen form). The resin is filtered and washed with water. The filtrate is treated with charcoal, filtered and evaporated in vacuo. The residue is recrystallized from water to provide 0.75 g of pure 7-β-D-arabinofuranosyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one.

1. temperaturecooled
2. customThe solution is evaporated in vacuo
3. dissolutionthe resulting residue is dissolved in water
4. additiontreated with 15 ml of wet Dowex 50×8 (in hydrogen form)
5. filtrationThe resin is filtered
6. washwashed with water
7. additionThe filtrate is treated with charcoal
8. filtrationfiltered
9. customevaporated in vacuo
10. customThe residue is recrystallized from water