HCID 14322318, compound → s-Triazolo(3,4-a)phthalazine

HRID 2231641Notes

Reaction equation

HRID 2231641 reaction equation
ClC[C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]2=[N:13][N:14]=[C:15](C3C=CC(OC)=CC=3)[N:5]2[N:4]=1>N1CCCC1>[N:13]1[N:14]=[CH:15][N:5]2[N:4]=[CH:3][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]=12

Participants

3

Reactant 1

HCID 14322318HCID 14322318, compound

Product 1

HCID 97337s-Triazolo(3,4-a)phthalazineYield 108.1%

Reagents, catalysts & solvents 1

HCID 31268PyrrolidineSolvent

Procedure

6-(Chloromethyl)-3-(4-methoxyphenyl)-1,2,4-triazolo[3,4-a]phthalazine (3 g) and pyrrolidine (30 ml) are heated at 100° C. for 8 h in autoclave. The amine excess is removed, the residue is washed with a small amount of water and crystallized from ethyl acetate, yielding 3-(4-methoxyphenyl)-6-[1-pyrrolidinyl)methyl]-1,2,4-triazolo[3,4-a]phthalazine (1.7 g). M.p. 184°-186° C.

Workup

  1. customThe amine excess is removed
  2. washthe residue is washed with a small amount of water
  3. customcrystallized from ethyl acetate

Sources & evidence

ORD record
ord-36155c3416204f3183723449e577de77
Source dataset
uspto-grants-1988_11
Patent number
US04783461

Reaction notes

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