Tetrahydrofuran → HCID 21285556, compound

Participants

Reaction Steps

7 g of triethylamine are added to a solution of 10.3 g of 2-diethylamino-4,6-diamino-5-cyanopyrimidine (prepared in accordance with Example 2) in 90 ml of tetrahydrofuran. Then 8.5 g of isobutyryl anhydride are added dropwise to this solution at 60° C. The reaction mixture is heated for 48 hours under reflux, concentrated by evaporation, and the residue is washed with diethyl ether, affording the title compound of formula ##STR24## with a melting point of 151°-152° C. (compound 1.3).

Provenance & Evidence