Tetrahydrofuran → HCID 21285556, compound

HRID 2231644Notes

Reaction equation

HRID 2231644 reaction equation
[CH2:1](N(CC)CC)C.[CH2:8]([N:10]([CH2:21][CH3:22])[C:11]1[N:16]=[C:15]([NH2:17])[C:14]([C:18]#[N:19])=[C:13]([NH2:20])[N:12]=1)[CH3:9].[O:23]1[CH2:27][CH2:26][CH2:25]C1>>[CH2:21]([N:10]([CH2:8][CH3:9])[C:11]1[N:12]=[C:13]([NH2:20])[C:14]([C:18]#[N:19])=[C:15]([NH:17][C:27](=[O:23])[CH:26]([CH3:1])[CH3:25])[N:16]=1)[CH3:22]

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 212855554,6-Diamino-2-(diethylamino)pyrimidine-5-carbonitrile

Product 1

HCID 21285556HCID 21285556, compound

Procedure

7 g of triethylamine are added to a solution of 10.3 g of 2-diethylamino-4,6-diamino-5-cyanopyrimidine (prepared in accordance with Example 2) in 90 ml of tetrahydrofuran. Then 8.5 g of isobutyryl anhydride are added dropwise to this solution at 60° C. The reaction mixture is heated for 48 hours under reflux, concentrated by evaporation, and the residue is washed with diethyl ether, affording the title compound of formula ##STR24## with a melting point of 151°-152° C. (compound 1.3).

Workup

  1. temperatureThe reaction mixture is heated for 48 hours
  2. temperatureunder reflux
  3. concentrationconcentrated by evaporation
  4. washthe residue is washed with diethyl ether

Sources & evidence

ORD record
ord-f94216ad02024e7ea1da7055707ce033
Source dataset
uspto-grants-1988_11
Patent number
US04783468

Reaction notes

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