Methanol → HCID 14281087, compound

HRID 2231645Notes

Reaction equation

HRID 2231645 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[CH3:21])[N:10]=2)[N:3]=1.[CH3:22][O-:23].[Na+].CO.[Na]>C(Cl)(Cl)Cl.O>[CH3:22][O:23][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[CH3:21])[N:10]=2)[N:3]=1

Participants

7

Reactant 4

HCID 887MethanolHCID 5360545SodiumHCID 10942334Sodium MethoxideHCID 21285507HCID 21285507, compound

Product 1

HCID 14281087HCID 14281087, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6212ChloroformSolvent

Procedure

To 4-chloro-6-methyl-2-(6-o-tolyl-2-pyridinyl)pyrimidine (2 g) was added sodium methoxide prepared from methanol (10 ml) and metallic sodium (0.19 g). After the mixture was left to stand at room temperature for 30 minutes, water (30 ml) and chloroform (100 ml) was added thereto, and then extracted. After the extract was dried over anhydrous magnesium sulfate, it was concentrated under reduced pressure to obtain 4-methoxy-6-methyl-2-(6-o-tolyl-2-pyridinyl)pyrimidine (1.9 g, yield 96%).

Workup

  1. waitAfter the mixture was left
  2. extractionextracted
  3. dry with materialAfter the extract was dried over anhydrous magnesium sulfate, it
  4. concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record
ord-ca6efacc3ef54212a30041f872ad8748
Source dataset
uspto-grants-1988_11
Patent number
US04783466

Reaction notes

Loading…