反应详情

6-Amino-3-methyl-5-(4-cyanophenyl)imino-1-n-propyluracil (5.00 g, 17.4 mmol) is dissolved in 75 ml of glyme and 4.2 ml (21.4 mmol) of diisopropylazodicarboxylate is added. The solution is then brought to reflux. The solution is refluxed 30 minutes and then filtered hot. The filter cake is washed with glyme (3×20 ml) and ether (3×30 ml) and airdried to give 1-methyl-8-(4-cyanophenyl)-3-n-propylxanthine.

1. temperatureto reflux
2. temperatureThe solution is refluxed 30 minutes
3. filtrationfiltered hot
4. washThe filter cake is washed with glyme (3×20 ml) and ether (3×30 ml)