HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethyl 4-cyano-3-(4-chloro-3-trifluoromethylphenyl)-2-phenylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 3-[4-Chloro-3-(trifluoromethyl)phenyl]prop-2-enenitrile | HCID 54176226 | — |
| Product | Ethyl 4-cyano-3-(4-chloro-3-trifluoromethylphenyl)-2-phenylbutanoate | HCID 14913228 | — |
Reaction Steps
20 g (0.086 mol) of 4-chloro-3-trifluoromethylcinnamonitrile dissolved in 80 cm3 of anhydrous THF are added in the course of 45 min at a temperature of between -12° C. and -15° C. The temperature is allowed to rise to -5° C. and the mixture is stirred for 1 hour 10 min before being hydrolyzed at between -5° C. and -10° C. with 50 cm3 of water and then 6N hydrochloric acid (approximately 40 cm3) to neutrality.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04785007 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-8c21ed8a10464296804e0218e7934781 |
| Source note | uspto-grants-1988_11 |