Triethylamine → HCID 3288130, compound

HRID 2231841Notes

Reaction equation

HRID 2231841 reaction equation
Cl.[NH2:2][CH2:3][C:4]#[N:5].C(N(CC)CC)C.[Cl:13][C:14]1[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=1[C:16](Cl)=[O:17]>C(Cl)(Cl)Cl.C(Cl)Cl>[C:4]([CH2:3][NH:2][C:16](=[O:17])[C:15]1[CH:19]=[CH:20][CH:21]=[CH:22][C:14]=1[Cl:13])#[N:5]

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 691102-Chlorobenzoyl chlorideHCID 11491918Aminoacetonitrile hydrochloride

Product 1

HCID 3288130HCID 3288130, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 6344DichloromethaneSolvent

Procedure

To a stirred mixture of 9.3 g (0.1 mole) aminoacetonitrile hydrochloride and 20.2 g (0.2 moles) triethylamine in 200 ml chloroform, 17.5 g (0.1 mole) o-chlorobenzoyl chloride in 25 ml methylene chloride were dropped in over 30 minutes in a moderately exothermic addition. The reaction mixture was washed twice with 75 ml water. On the second washing, solids separated which were filtered and washed well with water. Beige solids were obtained.

Workup

  1. additionwere dropped in over 30 minutes in a moderately exothermic addition
  2. washThe reaction mixture was washed twice with 75 ml water
  3. customOn the second washing, solids separated which
  4. filtrationwere filtered
  5. washwashed well with water
  6. customBeige solids were obtained

Sources & evidence

ORD record
ord-e72f89e3173c49d1856c9e346b2ca4b3
Source dataset
uspto-grants-1988_11
Patent number
US04785019

Reaction notes

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