3-(Trifluoromethyl)benzaldehyde → HCID 10562229, compound

HRID 2231855Notes

Reaction equation

HRID 2231855 reaction equation
[CH2:1]([O:3][C:4]([CH:6]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:5])[CH3:2].[F:26][C:27]([F:37])([F:36])[C:28]1[CH:29]=[C:30]([CH:33]=[CH:34][CH:35]=1)[CH:31]=O>ClCCl>[CH2:1]([O:3][C:4](=[O:5])/[CH:6]=[CH:31]/[C:30]1[CH:33]=[CH:34][CH:35]=[C:28]([C:27]([F:37])([F:36])[F:26])[CH:29]=1)[CH3:2]

Participants

4

Reactant 2

HCID 679903-(Trifluoromethyl)benzaldehydeHCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester

Product 1

HCID 10562229HCID 10562229, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

88.9 g of ethoxycarbonylmethylenetriphenylphosphorane are added dropwise, while cooling, to a solution of 34.0 g of 3-trifluoromethylbenzaldehyde in 400 ml of dichloromethane. The reaction mixture is stirred for one hour at room temperature, the solvent is evaporated off in vacuo and the residue is filtered with ether/hexane (4:1) over silica gel. Concentration by evaporation of the eluate yields the title compound in the form of white crystals; m.p. 40°-41° C.

Workup

  1. customthe solvent is evaporated off in vacuo
  2. filtrationthe residue is filtered with ether/hexane (4:1) over silica gel
  3. concentrationConcentration
  4. customby evaporation of the

Sources & evidence

ORD record
ord-6977ec5798cf4c05a70c8a65a967e145
Source dataset
uspto-grants-1988_11
Patent number
US04785004

Reaction notes

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