Hydrazine hydrate (1:1) → HCID 21284877, compound

HRID 2231869Notes

Reaction equation

HRID 2231869 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][N:13]2[C:17]([CH3:18])=[CH:16][CH:15]=[C:14]2[CH2:19][N:20]2C(=O)C3=CC=CC=C3C2=O)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].O.NN>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][N:13]2[C:17]([CH3:18])=[CH:16][CH:15]=[C:14]2[CH2:19][NH2:20])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13364782HCID 13364782, compound

Product 1

HCID 21284877HCID 21284877, compound

Procedure

6.0 g (0.015 mol) of 1-(2-(3,4-dimethoxyphenyl)-ethyl)-2-(phthalimido-methyl)-5-methyl-pyrrole (compare Example 4) and 7 ml (0.15 mol) of hydrazine hydrate are heated under reflux for 30 minutes. After the mixture has been concentrated, the residue is taken up in methylene chloride, the mixture is filtered, the filtrate is concentrated and the residue is chromatographed over a silica gel column.

Workup

  1. temperatureunder reflux for 30 minutes
  2. concentrationAfter the mixture has been concentrated
  3. filtrationthe mixture is filtered
  4. concentrationthe filtrate is concentrated
  5. customthe residue is chromatographed over a silica gel column

Sources & evidence

ORD record
ord-ed051f5f16b54248a68665763067fd79
Source dataset
uspto-grants-1988_11
Patent number
US04785010

Reaction notes

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