Glycine methyl ester hydrochloride → HCID 13534383, compound

HRID 2231875Notes

Reaction equation

HRID 2231875 reaction equation
[C:1]1(=[O:24])[N:5]([CH2:6][C:7](=O)[CH2:8][CH2:9][C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=O)[C:4](=[O:19])[C:3]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:2]12.Cl.[CH3:26][O:27][C:28](=[O:31])[CH2:29][NH2:30].C([O-])(=O)C.[Na+]>C(O)(=O)CC>[CH3:26][O:27][C:28]([CH2:29][N:30]1[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:9][CH:8]=[C:7]1[CH2:6][N:5]1[C:4](=[O:19])[C:3]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:2]2[C:1]1=[O:24])=[O:31]

Participants

5

Reactant 3

HCID 122755Glycine methyl ester hydrochlorideHCID 517045Sodium AcetateHCID 12582896HCID 12582896, compound

Product 1

HCID 13534383HCID 13534383, compound

Reagents, catalysts & solvents 1

HCID 1032Propionic AcidSolvent

Procedure

9.6 g (0.03 mol) of 5-phthalimido-1-phenyl-1,4-pentanedione, 5.0 g (0.04 mol) of glycine methyl ester hydrochloride and 3.2 g (0.04 mol) of anhydrous sodium acetate are stirred in 80 ml of propionic acid at 60° C. for 20 hours. Purification is by column chromatography. Solid phase: "Silica-Woelm", particle size 0.1 to 0.2 mm; manufacturer: Messrs. Woelm, Eschwege, Germany; mobile phase: methylene chloride.

Workup

  1. customPurification

Sources & evidence

ORD record
ord-6d138e80e5434db2a9306b4a26f0759b
Source dataset
uspto-grants-1988_11
Patent number
US04785010

Reaction notes

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