Glycine methyl ester hydrochloride → HCID 13534389, compound

HRID 2231879Notes

Reaction equation

HRID 2231879 reaction equation
[C:1]1(=[O:20])[N:5]([CH2:6][C:7](=O)[CH2:8][CH2:9][C:10](=O)[CH2:11][CH3:12])[C:4](=[O:15])[C:3]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:2]12.Cl.[CH3:22][O:23][C:24](=[O:27])[CH2:25][NH2:26].C([O-])(=O)C.[Na+]>C1(O)CCCCC1>[CH3:22][O:23][C:24]([CH2:25][N:26]1[C:10]([CH2:11][CH3:12])=[CH:9][CH:8]=[C:7]1[CH2:6][N:5]1[C:4](=[O:15])[C:3]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:2]2[C:1]1=[O:20])=[O:27]

Participants

5

Reactant 3

HCID 122755Glycine methyl ester hydrochlorideHCID 517045Sodium AcetateHCID 125828942-(2,5-Dioxoheptyl)-1H-isoindole-1,3(2H)-dione

Product 1

HCID 13534389HCID 13534389, compound

Reagents, catalysts & solvents 1

HCID 7966CyclohexanolSolvent

Procedure

6.8 g (0.025 mol) of 7-phthalimido-3,6-heptanedione, 3.5 g (0.028 mol) of glycine methyl ester hydrochloride and 2.3 g (0.028 mol) of sodium acetate are stirred in 150 ml of cyclohexanol at 60° C. for 13 hours and the mixture is worked up as in Example 22.

Sources & evidence

ORD record
ord-9618e8c4a6844b0fb2c128f0d12c11ef
Source dataset
uspto-grants-1988_11
Patent number
US04785010

Reaction notes

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