Phosphorus sulfide (P2S5) → HCID 21285249, compound

HRID 2231957Notes

Reaction equation

HRID 2231957 reaction equation
P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:2].[NH2:15][C:16]1[C:21](=[O:22])[N:20]([CH3:23])[C:18](=[O:19])[C:17]=1[C:24]#[N:25]>>[NH2:15][C:16]1[C:21](=[O:22])[N:20]([CH3:23])[C:18](=[O:19])[C:17]=1[C:24](=[S:2])[NH2:25]

Participants

3

Reactant 2

HCID 14817Phosphorus sulfide (P2S5)HCID 21285253HCID 21285253, compound

Product 1

HCID 21285249HCID 21285249, compoundYield 59%

Conditions

Temperature
100 °C

Procedure

A mixture of 100 parts of phosphorus pentasulfide and 450 parts of methylglycol is heated at the boil for 0.5 hour, after which 90 parts of 3-amino-2-cyano-N-methylmaleimide are introduced into this solution at 100° C. The mixture is stirred for 3 hours at 100° C. and then overnight at room temperature. The resulting precipitate is filtered off under suction, washed with methanol and then with water, and dried to give 65.1 parts (59% of theory) of 3-amino-2-thiocarbamyl-N-methylmaleimide.

Workup

  1. temperatureis heated at the boil for 0.5 hour
  2. customovernight
  3. customat room temperature
  4. filtrationThe resulting precipitate is filtered off under suction
  5. washwashed with methanol
  6. dry with materialwith water, and dried

Sources & evidence

ORD record
ord-45004b2d456343d9b36ba7e508096a7d
Source dataset
uspto-grants-1988_11
Patent number
US04785116

Reaction notes

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