Phosphorus sulfide (P2S5) → HCID 21285249, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 100 parts of phosphorus pentasulfide and 450 parts of methylglycol is heated at the boil for 0.5 hour, after which 90 parts of 3-amino-2-cyano-N-methylmaleimide are introduced into this solution at 100° C. The mixture is stirred for 3 hours at 100° C. and then overnight at room temperature. The resulting precipitate is filtered off under suction, washed with methanol and then with water, and dried to give 65.1 parts (59% of theory) of 3-amino-2-thiocarbamyl-N-methylmaleimide.

Provenance & Evidence