Hydrochloric Acid → HCID 21285251, compound

HRID 2231960Notes

Reaction equation

HRID 2231960 reaction equation
CN(C)C=[N:4][C:5]1[S:9][N:8]=[C:7]([C:10]#[N:11])[C:6]=1[C:12]#[N:13].C(O)C.Cl>O>[NH2:4][C:5]1[S:9][N:8]=[C:7]([C:10]#[N:11])[C:6]=1[C:12]#[N:13]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 54385684HCID 54385684, compound

Product 1

HCID 21285251HCID 21285251, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 45.3 parts of N,N-dimethyl-N'-(3,4-dicyanoisothiazol-5-yl)-formamidine, 400 parts of ethanol and 60 parts of concentrated hydrochloric acid is heated at the boil for 2.5 hours, after which it is introduced into 400 parts of water. The colorless precipitate is filtered off under suction, washed with water and dried to give 28.6 parts (87% of theory) of 5-aminoisothiazole-3,4-dicarbonitrile.

Workup

  1. temperatureis heated at the boil for 2.5 hours
  2. filtrationThe colorless precipitate is filtered off under suction
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-0cb5fe07597141849b590bf460fabdaf
Source dataset
uspto-grants-1988_11
Patent number
US04785116

Reaction notes

Loading…