HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-(Diazomethylene)bis(benzene) → N-t-butoxycarbonyl DL-homoserine benzhydryl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-(Diazomethylene)bis(benzene) | HCID 61230 | — |
| Reactant | 2-(((Tert-butoxy)carbonyl)amino)-4-hydroxybutanoic acid | HCID 4118627 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-t-butoxycarbonyl DL-homoserine benzhydryl ester | HCID 13066458 | 81.5% |
Reaction Steps
6 g of the obtained N-t-butoxycarbonyl DL-homoserine was dissolved in 100 ml of methylene chloride, and 50 ml of a methylene chloride solution containing 6 g of diphenyldiazomethane was added dropwise thereto over an hour. After completion of the reaction, the reaction mixture was concentrated to a small volume, and petroleum ether was added thereto. The formed crystals were filtered off to obtain 8.6 g of N-t-butoxycarbonyl DL-homoserine benzhydryl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04785090 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-0db094c08a004530b12a9276bab5ae27 |
| Source note | uspto-grants-1988_11 |