反应详情

To a solution of 12.0 g of the (2-tritylaminothiazol-4-yl)methoxyphthalimide in 400 ml of dichloromethane was added 1.161 g of hydrazine hydrate with cooling, and the mixture was stirred at room temperature for 5 hours. The formed precipitates were removed by filtration, the dichloromethane layer was washed with 300 ml of 10% ammonia water three times and then with 300 ml of saturated saline twice, dried on anhydrous magnesium sulfate, and concentrated to dryness to obtain 8.74 g of (2-tritylaminothiazol-4-yl)methoxyamine.

1. temperaturewith cooling
2. customThe formed precipitates
3. customwere removed by filtration
4. washthe dichloromethane layer was washed with 300 ml of 10% ammonia water three times
5. dry with materialwith 300 ml of saturated saline twice, dried on anhydrous magnesium sulfate
6. concentrationconcentrated to dryness