(2-Triphenylmethylamino-4-thiazolyl)glyoxylic acid → HCID 13578647, compound

HRID 2231987Notes

Reaction equation

HRID 2231987 reaction equation
[C:1]([NH:20][C:21]1[S:22][CH:23]=[C:24]([C:26](=O)[C:27]([OH:29])=[O:28])[N:25]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:31]([NH:50][C:51]1[S:52][CH:53]=[C:54]([CH2:56][O:57][NH2:58])[N:55]=1)([C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1)([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>CO>[C:1]([NH:20][C:21]1[S:22][CH:23]=[C:24](/[C:26](=[N:58]/[O:57][CH2:56][C:54]2[N:55]=[C:51]([NH:50][C:31]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)([C:38]3[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=3)[C:44]3[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=3)[S:52][CH:53]=2)/[C:27]([OH:29])=[O:28])[N:25]=1)([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 11133448(2-Triphenylmethylamino-4-thiazolyl)glyoxylic acidHCID 21285079(2-Tritylaminothiazol-4-yl)methoxyamine

Product 1

HCID 13578647HCID 13578647, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3.1 g of 2-(2-tritylaminothiazol-4-yl)glyoxalic acid was dissolved in 170 ml of methanol, 2.9 g of the (2-tritylaminothiazol-4-yl)methoxyamine was added thereto, and stirred at room temperature for 4 hours. The formed precipitates were filtered off and washed with 20 ml of methanol to obtain 5.1 g of (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-tritylaminothiazol-4-yl)methoxyimino]acetic acid.

Workup

  1. customThe formed precipitates
  2. filtrationwere filtered off
  3. washwashed with 20 ml of methanol

Sources & evidence

ORD record
ord-f5c6761cf1224a8fb2160dcd74b89c4c
Source dataset
uspto-grants-1988_11
Patent number
US04785090

Reaction notes

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