Hydrochloric Acid → HCID 21284125, compound

HRID 2232002Notes

Reaction equation

HRID 2232002 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:5]=1[N:11]1[C:15]([C:16]([O:18]CC)=[O:17])=[CH:14][N:13]=[CH:12]1)([CH3:3])=[CH2:2].Cl>[OH-].[Na+]>[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:5]=1[N:11]1[C:15]([C:16]([OH:18])=[O:17])=[CH:14][N:13]=[CH:12]1)([CH3:3])=[CH2:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21284129HCID 21284129, compound

Product 1

HCID 21284125HCID 21284125, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

8.0 g (0.03 mol) of ethyl 1-(2-isopropenyl-6-methylphenyl)imidazole-5-carboxylate (see Example 128) are heated for 2 hours at 80° C. with 100 ml of 2N sodium hydroxide solution. The mixture is cooled and acidified to pH 3 with concentrated hydrochloric acid, and the precipitate is filtered off under suction. 5.2 g (72% of theory) of 1(2-isopropenyl-6-methylphenyl)imidazole-5-carboxylic acid, a colorless solid of melting point 204° C. (decomposition), are obtained.

Workup

  1. temperatureThe mixture is cooled
  2. filtrationthe precipitate is filtered off under suction

Sources & evidence

ORD record
ord-60ac92c7b017474696a0941624f32ada
Source dataset
uspto-grants-1988_11
Patent number
US04786312

Reaction notes

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