Carbon Dioxide → 8-fluoro-4,5-dihydro-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one

HRID 223204Notes

Reaction equation

HRID 223204 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[N:13][C:14](C(O)=O)=[C:10]3[CH2:9][N:8]([CH3:18])[C:7](=[O:19])[C:6]=2[CH:20]=1.C(=O)=O.CCCCCC>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[N:13][CH:14]=[C:10]3[CH2:9][N:8]([CH3:18])[C:7](=[O:19])[C:6]=2[CH:20]=1

Participants

5

Reactant 3

HCID 280Carbon DioxideHCID 8058HexaneHCID 134757Ro 15-3890

Product 1

HCID 229145898-fluoro-4,5-dihydro-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

9.2 g of 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid are heated to 290°. After completion of the carbon dioxide evolution, the product is dissolved in chloroform and treated with hexane. The precipitated crystals are filtered off under suction and dried. There is obtained 8-fluoro-4,5-dihydro-5-methyl-6H-imidazo[1,5-a][1,4]-benzodiazepin-6-one of melting point 236°.

Workup

  1. filtrationThe precipitated crystals are filtered off under suction
  2. customdried

Sources & evidence

ORD record
ord-2b9fab479df442e9921b9621f0b79563
Source dataset
uspto-grants-1982_10
Patent number
US04352818

Reaction notes

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