HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Dioxide → 8-fluoro-4,5-dihydro-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Dioxide | HCID 280 | — |
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Ro 15-3890 | HCID 134757 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 8-fluoro-4,5-dihydro-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one | HCID 22914589 | — |
Reaction Steps
9.2 g of 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid are heated to 290°. After completion of the carbon dioxide evolution, the product is dissolved in chloroform and treated with hexane. The precipitated crystals are filtered off under suction and dried. There is obtained 8-fluoro-4,5-dihydro-5-methyl-6H-imidazo[1,5-a][1,4]-benzodiazepin-6-one of melting point 236°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04352818 |
| Source dataset | uspto-grants-1982_10 |
| ORD ID | ord-2b9fab479df442e9921b9621f0b79563 |
| Source note | uspto-grants-1982_10 |