Hydrochloric Acid → HCID 14347793, compound

HRID 2232082Notes

Reaction equation

HRID 2232082 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[N:8]([C:13]1[S:14][CH:15]=[CH:16][CH:17]=1)[CH:7]=[C:6]([C:18]([O:20]CC)=[O:19])[C:5]2=[O:23].Cl>C(O)(=O)C>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[N:8]([C:13]1[S:14][CH:15]=[CH:16][CH:17]=1)[CH:7]=[C:6]([C:18]([OH:20])=[O:19])[C:5]2=[O:23]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14347792HCID 14347792, compound

Product 1

HCID 14347793HCID 14347793, compoundYield 72.8%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To ethyl 6,7-difluoro-1-(2-thienyl)-1,4-dihydro-4-oxoquinoline-3-carboxylate (0.6 g) are added 90% acetic acid (3 ml) and conc. hydrochloric acid (0.8 ml), and the mixture is refluxed for one hour. After allowing to cool, the precipitated crystals are separated by filtration, and washed with water, ethanol and ether in this order to give 6,7-difluoro-1-(2-thienyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (0.4 g) as colorless crystals, m.p. 245°-246° C.

Workup

  1. temperaturethe mixture is refluxed for one hour
  2. temperatureto cool
  3. customthe precipitated crystals are separated by filtration
  4. washwashed with water, ethanol and ether in this order

Sources & evidence

ORD record
ord-b4903ea2164d428a9211122897e9b1a5
Source dataset
uspto-grants-1988_11
Patent number
US04786649

Reaction notes

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