HCID 13959885, compound → 3-Aminomethyl-1-benzyl-4-chloropyrrolidine

HRID 2232087Notes

Reaction equation

HRID 2232087 reaction equation
[CH2:1]([N:8]1[CH2:12][CH:11]([Cl:13])[CH:10]([CH2:14][N:15]=[N+]=[N-])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[C].[Pd].C(O)C>[NH2:15][CH2:14][CH:10]1[CH:11]([Cl:13])[CH2:12][N:8]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:9]1

Participants

4

Reactant 1

HCID 13959885HCID 13959885, compound

Product 1

HCID 139598953-Aminomethyl-1-benzyl-4-chloropyrrolidineYield 110.1%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To 1-benzyl-3-azidomethyl-4-chloropyrrolidine (3.0 g) are added ethanol (50 ml) and 10 % palladium carbon (0.5 g), and catalytic reduction is carried out under a hydrogen pressure of from 3 to 4 atm. at 50° C. After removing the catalyst from the mixture by a filteration, the resultant is concentrated to give 3-aminomethyl -1-benzyl-4-chloropyrrolidine (2.96g) as an oil.

Workup

  1. customat 50° C
  2. customAfter removing the catalyst from the mixture by a filteration
  3. concentrationthe resultant is concentrated

Sources & evidence

ORD record
ord-1dd690f3424c4888b6f25b1127b9f1f6
Source dataset
uspto-grants-1988_11
Patent number
US04786649

Reaction notes

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