HCID 20523293, compound → HCID 10013995, compound

HRID 223209Notes

Reaction equation

HRID 223209 reaction equation
[CH3:1][N:2]1[C:8](=[O:9])[C:7]2[CH:10]=[CH:11][CH:12]=[CH:13][C:6]=2[N:5]2[CH:14]=[N:15][C:16]([NH:17]C(OCC3C=CC=CC=3)=O)=[C:4]2[CH2:3]1>CO.[Pd]>[NH2:17][C:16]1[N:15]=[CH:14][N:5]2[C:6]3[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=3[C:8](=[O:9])[N:2]([CH3:1])[CH2:3][C:4]=12

Participants

4

Reactant 1

HCID 20523293HCID 20523293, compound

Product 1

HCID 10013995HCID 10013995, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

34 g (93.8 mmol) of benzyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carbamate are hydrogenated at room temperature and normal pressure in 300 ml of methanol in the presence of 4 g of 10 percent palladium/carbon. After removal of the catalyst and evaporation, the residue is recrystallized from ethyl acetate and hexane. There is obtained 3-amino-4,5-dihydro-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one of melting point 202°-204°.

Workup

  1. customare hydrogenated at room temperature
  2. customAfter removal of the catalyst and evaporation
  3. customthe residue is recrystallized from ethyl acetate and hexane

Sources & evidence

ORD record
ord-86bc812b8563416a81d53d9468f66fbf
Source dataset
uspto-grants-1982_10
Patent number
US04352818

Reaction notes

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