反应详情

To a refluxing solution of 0.174 g of [3-(8-isoquinolinyl)propyl]-1H-isoindole-1,3-(2H)-dione in 8 mL of ethanol was added 0.12 mL of hydrazine hydrate and the reaction was stirred at reflux for 5.5 hours. The solvent was removed under reduced pressure and the residue was triturated with chloroform. The chloroform extract was concentrated to an oil which was passed through a short column of silica gel (chloroform-methanol-triethylamine; 1:4:15) to yield 0.103 g of 8-isoquinolinepropanamine as an oil.

1. temperatureat reflux for 5.5 hours
2. customThe solvent was removed under reduced pressure
3. customthe residue was triturated with chloroform
4. extractionThe chloroform extract
5. concentrationwas concentrated to an oil which