(E)-4-(4-isoquinolinyl)-3-buten-1-amine → 4-Isoquinolinebutanamine

HRID 2232148Notes

Reaction equation

HRID 2232148 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](/[CH:11]=[CH:12]/[CH2:13][CH2:14][NH2:15])=[CH:3][N:2]=1>C(O)C.[Pd]>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH2:11][CH2:12][CH2:13][CH2:14][NH2:15])=[CH:3][N:2]=1

Participants

4

Reactant 1

HCID 14750834(E)-4-(4-isoquinolinyl)-3-buten-1-amine

Product 1

HCID 149941264-IsoquinolinebutanamineYield 88.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 1 g of (E)-4-(4-isoquinolinyl)-3-buten-1-amine in 20 mL of ethanol was hydrogenated over 0.12 g of 10% Pd/C at room temperature and atmospheric pressure. After 8 hours, the catalyst was removed by filtration and the filtrate was concentrated to yield 0.893 g of 4-isoquinolinebutanamine.

Workup

  1. customthe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-61506bc2486d485e9a93464b032aea6c
Source dataset
uspto-grants-1988_11
Patent number
US04786646

Reaction notes

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