Dextromethorphan hydrobromide monohydrate → Dextromethorphan

HRID 2232185Notes

Reaction equation

HRID 2232185 reaction equation
[CH3:1][N:2]1[C@H:11]2[CH2:12][C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:14]=3[C@:5]3([C@@H:10]2[CH2:9][CH2:8][CH2:7][CH2:6]3)[CH2:4][CH2:3]1.O.Br>O>[CH3:1][N:2]1[C@H:11]2[CH2:12][C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:14]=3[C@:5]3([C@@H:10]2[CH2:9][CH2:8][CH2:7][CH2:6]3)[CH2:4][CH2:3]1

Participants

3

Reactant 1

HCID 5462351Dextromethorphan hydrobromide monohydrate

Product 1

HCID 5360696Dextromethorphan

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

10 g dextromethorphan hydrobromide and 60 g of the dry resin (calculated on a moisture free basis) are dispersed in deionized water and stirred at 50° C. for about 24 hours to obtain essentially total binding of dextromethorphan to the resin. Residual free dextromethorphan is checked at intervals with a UV-spectrophotometer. At the end point, residual free drug was found to be negligible. The resinate is filtered and dried to constant weight at 50° C. under vacuum to yield resinate #1.

Sources & evidence

ORD record
ord-351dda80fa4e464d8d2cbaeb7637f8e4
Source dataset
uspto-grants-1988_11
Patent number
US04788055

Reaction notes

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