Dextromethorphan hydrobromide monohydrate → Dextromethorphan

Participants

Reaction Conditions

Reaction Steps

10 g dextromethorphan hydrobromide and 60 g of the dry resin (calculated on a moisture free basis) are dispersed in deionized water and stirred at 50° C. for about 24 hours to obtain essentially total binding of dextromethorphan to the resin. Residual free dextromethorphan is checked at intervals with a UV-spectrophotometer. At the end point, residual free drug was found to be negligible. The resinate is filtered and dried to constant weight at 50° C. under vacuum to yield resinate #1.

Provenance & Evidence